2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140420
    Boc-Aminooxy-PEG4-CH2-Boc 2062663-63-0
    Boc-Aminooxy-PEG4-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Aminooxy-PEG4-CH2-Boc
  • HY-133478
    TCO-PEG11-TCO
    TCO-PEG11-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-PEG11-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG11-TCO
  • HY-140107
    Azidoethyl-SS-PEG2-Boc 2144777-83-1
    Azidoethyl-SS-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azidoethyl-SS-PEG2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azidoethyl-SS-PEG2-Boc
  • HY-132077
    THP-PEG16-THP
    THP-PEG16-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG16-THP
  • HY-141290
    Bis-(m-PEG8-amido)-hexanoic acid 2353409-77-3
    Bis-(m-PEG8-amido)-hexanoic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-(m-PEG8-amido)-hexanoic acid
  • HY-140379
    1,1,1-Trifluoroethyl-PEG4-Tos 1872433-61-8
    1,1,1-Trifluoroethyl-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    1,1,1-Trifluoroethyl-PEG4-Tos
  • HY-140437
    t-Boc-Aminooxy-PEG7-methane 2055041-27-3
    t-Boc-Aminooxy-PEG7-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG7-methane
  • HY-141053
    N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 2107273-54-9
    N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5
  • HY-140653
    Amine-PEG5000-thiol
    Amine-PEG5000-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG5000-thiol
  • HY-W190796
    Mal-PEG3-NH2 2170654-70-1
    Mal-PEG3-NH2 is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 is a crosslinking reagent with a PEG spacer.
    Mal-PEG3-NH2
  • HY-140418
    t-Boc-Aminooxy-PEG12-NHS ester
    t-Boc-Aminooxy-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG12-NHS ester
  • HY-138420
    m-PEG7-Silane
    m-PEG7-Silane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG7-Silane
  • HY-138766
    Propargyl-PEG11-amine
    Propargyl-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG11-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG11-amine
  • HY-130905
    DSPE-PEG46-NH2
    DSPE-PEG46-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG46-NH2
  • HY-130904
    DSPE-PEG47-acid
    DSPE-PEG47-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG47-acid
  • HY-133465
    Tetrazine-Ph-PEG4-Ph-aldehyde
    Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-PEG4-Ph-aldehyde
  • HY-138434
    Fmoc-NH-PEG14-acid
    Fmoc-NH-PEG14-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG14-acid
  • HY-140291
    DBCO-PEG4-NH-Boc 2353410-17-8
    DBCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-NH-Boc
  • HY-140220
    Azido-PEG35-amine 2301851-71-6
    Azido-PEG35-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG35-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG35-amine
  • HY-140696C
    m-PEG20000-OH 9004-74-4
    m-PEG20000-OH can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Nanoscale micelles can be prepared by using amphiphilic block copolymers to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.
    m-PEG20000-OH
PROTAC Linkers Isoform Comparison

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